Telomere Reverse Transcriptase (TERT) rs2735940 Increases Cancer Risk
نویسندگان
چکیده
منابع مشابه
Telomere Reverse Transcriptase (TERT) rs2735940 Increases Cancer Risk
BACKGROUND Telomerase reverse transcriptase (TERT) rs2735940 polymorphism was found to be associated with increased cancer risk. However, recent studies reported controversial results. The aim of our study was to detect its relationship with cancer risk. MATERIAL AND METHODS EMBASE and PubMed databases were searched for all publications until October 2014. ORs and 95% CIs were applied to inve...
متن کاملTranscriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase reverse transcriptase (TERT), the catalytic component of telomerase. Transcription factor binding, chromatin status as well as epigenetic modifi...
متن کاملAssociation between the telomerase reverse Transcriptase (TERT) rs2736098 polymorphism and cancer risks: a meta-analysis
Previous studies showed that genetic polymorphisms of TERT (telomere reverse transcriptase) were considered to be closely correlated with the susceptibility of cancers. However, in case of TERT rs2736098, two meta-analyses published in 2012 have shown that it has no correlation with cancer risks, whereas a case-control study and a meta-analysis published in 2013 have shown it can be used as a p...
متن کاملThe TERT rs2736100 polymorphism increases cancer risk: A meta-analysis
Abnormal telomerase activity is implicated in cancer initiation and development. The rs2736100 T > G polymorphism in the telomerase reverse transcriptase (TERT) gene, which encodes the telomerase catalytic subunit, has been associated with increased cancer risk. We conducted a meta-analysis to more precisely assess this association. After a comprehensive literature search of the PubMed and EMBA...
متن کاملCancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications
The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of linear chromosomes, and attenuates or prevents telomere erosion associated with cell divisions. By lengthening telomeres, telomerase extends cellular life-span or even induces immortalization. Consistent with its functional act...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Science Monitor
سال: 2015
ISSN: 1643-3750
DOI: 10.12659/msm.893087